Desflurane
Desflurane : Synthesized in 1959-1966 First use in human 1988 available for general use in clinical start from 1993 The structure of Desflurane is similar to isoflurane Physical properties : It is colorless stored in amber colored bottle without preservative Not broken down by soda lime, light or metal Non-flammable Pungent smell MAC with oxygen is 6% MAC is 3% with 60% nitrous oxide Mac in children 9% (7 with N20) Blood/gas solubility co-eff 0.42 Oil/gas solubility co-eff 18.7 Metabolism : Approximately 0.02% of the inhaled desflurane is metabolized in the body by deflurination to trifluro-acetic acid which is excreted in urine It is delivered through special vaporizer (TEC6) It is a popular anesthetic for day care surgery. Induction and recovery is fast, cognitive and motor impairment are short lived It irritates the air passages producing cough and Laryngospasam. ACTION ON RESPIRATORY SYSTEM : Res...
